3. T. Denny Sanford

Amount Donated in 2010: $162.5 Million

Net Worth: $600 Million

Beneficiaries: Sanford-Burnham Medical Research Institute, Sanford Health Foundation and the Florida Hospital for Children.

The Chairman and CEO of United National Corp. Thomas Danny Sanford is a Banking Businessman and remarkable philanthropist of South Dakota. In 2007, he donated $400 million to Sioux Valley Hospitals and Health System, which later was renamed into Sanford Health Foundation. Wikipedia states Sanford's total philanthropic gifts have exceeded $500 million till date. He was also named as one of the top 50 most generous philanthropists in November, 2006.