4. Irwin and Joan Jacobs

Amount Donated in 2010: $119.5 million

Net Worth: $1.15 Billion

Beneficiaries: University of California at San Diego Health System, Joan and Irwin Jacobs Fund at the Jewish Community Foundation of San Diego.

An Electrical Engineer by profession and the Co-Founder and Former chairman of Qualcomm, the wireless communications company, Irwin M. Jacobs along with his wife Joan Jacobs helps deserving students in the fields of Engineering and Computer Science through providing fellowships and scholarships. A significant amount of their donations also goes to UCSD Health Systems.