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Indian-American Researchers Find New Target To Control Diabetes
NEW YORK: In a thrilling discovery, two Indian-American researchers have identified a new potential therapeutic target for controlling high blood sugar - a finding that could help millions suffering from type 2 diabetes worldwide.
Researchers showed that lipid molecules called phosphatidic acids enhance glucose production in the liver.
The findings suggest that inhibiting or reducing production of phosphatidic acids may do the opposite.
"This study establishes a role for phosphatidic acids in enhancing glucose production by the liver and identifies enzymes involved in the synthesis of phosphatidic acids as potential drug targets," explained Anil Agarwal, a professor of internal medicine at University of Texas' Southwestern Medical Centre.
These observations were made while studying a mouse model of lipodystrophy, a rare metabolic disease in which the body is devoid of fat.
Lipodystrophy patients often develop diabetes and accumulate fat in the liver because of an imbalance in the body's ability to properly regulate lipids and glucose.
The causal gene 'AGPAT2' which is involved in the synthesis of phosphatidic acid and triglycerides was removed in the mice - resulting in rodents with generalised lipodystrophy.
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Source: IANS
