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Indian-American Researchers Find New Target To Control Diabetes
The research team then examined what impact this genetic manipulation had on phosphatidic acids and glucose production.
"We expected the levels of phosphatidic acids to go down. However, in examining the livers of these lipodystrophic mice, we unexpectedly found high levels of this lipid class," added lead author Shireesha Sankella, a post-doctoral researcher in the division of nutrition and metabolic diseases.
This led to the identification of new targets involved in the production of phosphatidic acids.
The buildup of these lipid molecules was due to an increase in the levels of two enzymes in the liver - diacylglycerol kinase and phospholipase D.
Researchers also discovered a marked increase in glucose production in the livers of the lipodystrophic mice.
The lack of normal insulin signaling in these lipodystrophic mice led to unrestricted production of phosphatidic acid, contributing to development of hyperglycemia or high blood sugar.
"Besides revealing a new potential therapy to test for treatment of diabetes, the findings may have implications in understanding how cancer develops," Agarwal noted.
Increased phosphatidic acid levels may play an important role in a metabolic pathway that supplies energy to cancer cells, said the study published in the Journal of Biological Chemistry.
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Source: IANS
