Processing .....please wait.. 
The article has been forwarded.... 
Indian-American Leads New Potential Treatment For Diabetes
People with this mutation had high blood glucose and problems of insulin secretion - the "hallmarks of type 2 diabetes", Prabhakar said.
But it was unclear how the mutation was causing the symptoms, or whether it caused them on its own or in concert with other genes associated with Type 2 diabetes.
To study the role of MADD in diabetes, Prabhakar and his colleagues developed a mouse model in which the MADD gene was deleted from the insulin-producing beta cells. All such mice had elevated blood glucose levels, which the researchers found was due to insufficient release of insulin.
"We didn't see any insulin resistance in their cells, but it was clear that the beta cells were not functioning properly," Prabhakar said.
Examination of the beta cells revealed that they were packed with insulin. "The cells were producing plenty of insulin, they just weren't secreting it," he said.
Read More:
Indian Diplomat In New York Arrested For Visa Fraud
Enhance Attention Via Smartphones: Indian American Scientist
Source: PTI
