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Indian American Makes Breakthrough in Treatment of Liver Disease
"We have showed that human liver cells could be used to build engineered liver tissue and that this liver tissue could function once implanted in the body. So far, we are able to do this in mice. We need to make them bigger in order to help patients with liver disease."
She added "Tissue engineering has already created artificial skin and cartilage and bone that has helped many millions. Artificial trachea and bladder and blood vessels are also in humans. We will follow the same path that others have laid out for us for the liver".
"The main challenges are to get the liver cells to function like liver cells so they can support the patient, getting enough liver cells for a patient (billions are needed), and ways to implant them so they have enough nutrients through blood vessels (this is called vascularization). We think we have made good progress on the functional side begins to address the cell sourcing and vascularization issues," she added, reports Sinha.
Temporary maintenance of the functioning of normal liver cells (after they are removed from the body) will be made possible as a result of the research done by Bhatia.
