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Indian-Origin Scientists Challenge Cancer Biology Dogma
Henning Walczak, scientific director of Cancer Research UK and chairman of Cancer Biology at University College London, reacting to this publication, said in an e-mail: "In healthy individuals, A20, also known as TNFAIP3, works beneficially to clear invading microbes. However, if A20 cannot function as a result of hereditary mutations or infection, it results in serious pathologies, including cancer."
"Before this work, there was no animal model to understand how this critical tumour suppressor works. Having an animal model now, significantly improves our ability to investigate how A20 works, and this study already goes a long way in clarifying how A20 fails to work properly in patients and, as a consequence thereof, in developing potential cancer therapeutics", he concludes.
Chozha Rathinam and Teruki Dainichi, currently at Kyoto University (Japan), are the other authors in this publication.
Cancers figure among the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases and 8.2 million cancer related deaths in 2012, according to the World Health Organisation (WHO). The number of new cases is expected to rise by about 70 per cent over the next 2 decades, according to WHO.
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Source: IANS
