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India-Born Scientist's Team Uses DNA Rings For Cancer Detection
In a media release, the school painted a futuristic scenario where "You pop a pill into your mouth and swallow it. It dissolves, releasing tiny particles that are absorbed and cause only cancerous cells to secrete a specific protein into your bloodstream".
"Two days from now, a finger-prick blood sample will expose whether you have got cancer and even give a rough idea of its extent."
A paper describing the findings of this proof-of-principle study was published online Feb 23 in the Proceedings of the National Academy of Sciences.
"Although the minicircles were injected intravenously to the mice in this study, it should eventually prove possible to deliver them orally via a pill," Gambhir said.
"We haven't got it down to a pill yet, but the oral delivery part of this is likely a solvable problem -- only a few years off, not five or 10 years off."
It would take much more time than that to prove that the approach was safe to use in humans, though, Gambhir cautioned.
Eventually, he said, he foresaw variations, such as adding a second gene to the minicircles.
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Source: IANS
