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Indian Scientist Develops Potential Non-Insulin Diabetes Drug
NEW YORK: A young Indian scientist has developed a potential non-insulin drug candidate for diabetic patients that can help eliminate the risk of low-blood glucose shock in case of an insulin overdose.
Arnab De, a PhD in Microbiology and Immunology from Columbia University here, has developed the non-insulin drug candidate in collaboration with Richard DiMarchi of Indiana University.
Patients use insulin to keep their sugar levels in check, an overdose of insulin can lead to low blood-glucose (hypoglycemia), which may cause diabetic-coma and be life-threatening. Insulin treatment has also been reported to cause weight-gain that may exacerbate a diabetic condition, De told
"We find that there is a peptide hormone in the gut called GLP1 that increases the secretion of insulin only when the blood glucose is high. This effectively eliminates the risk of hypoglycemic shock. Another advantage is that GLP1 administration has been found to stimulate weight-loss.
The hormone offers the promise of revolutionising the treatment of Type II diabetes and reduce obesity," he said.
Regarding the clinical trial of the new drug, De said that GLP-1 has an extremely short half-life of two minutes and this instability has impeded its effective use in patients.
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Source: PTI
