Indian-Origin Scientists' Important Discovery in Malaria

Indian-Origin Scientists' Important Discovery in Malaria

By SiliconIndia   |   Tuesday, 31 January 2012, 08:58 Hrs
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Bangalore: A group of scientists of Indian-origin have come up with a fundamental malaria discovery, understanding how the disease is caused by the malaria parasites.

Kasturi Hakdar and Suva Bhattacharjee from University of Notre Dame’s Center for Rare and Neglected Diseases led the team of researchers. They were successful in finding out how parasites target proteins to the surface of the red blood cell which results in the blocking of blood vessels

The other scientists involved in the team were-Robert Stahelin of the Indiana University school of Medicine-South Bend, and David and Kaye Speicher from university of Pennsylvania’s Wistar Institute. They discovered that for host-targeted malaria proteins the first thing to do is adhering to the lipid phosphatidylinositol 3-phosphate, PI (3) P, in the ER (Endoplasmic Reticulum).

The team also came up with the conclusion that adhering to PI (3) P lipid is the gate keeper to control the transferring of the disease and this can occur without Plasmepsin V action.

Haldar and Bhattacharjee mainly specializes in malaria parasite biology and pathogenesis.

The interdisciplinary teamwork of these scientists explains a basic, new cellular function, whose disruption can provide new therapies that are immediately needed for malaria.


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