Artificial intelligence boosts drug delivery to eradicate malaria

Wednesday, 14 November 2018, 04:11 Hrs
33
cmt right
38
Comment Right
74
cmt right
13
cmt right
Printer Print Email Email


Using the next generation Artificial Intelligence (AI)-based tools, a team of researchers has developed a new end-to-end drug discovery pipeline to eradicate malaria.

Insilico Taiwan, a Taipei-based subsidiary of Insilico Medicine, announced the results in a paper published in Scientific Reports, a journal published by the Nature Publishing Group.

Plasmodium falciparum, the most dangerous human malaria parasite, is believed to cause hundreds of millions of illnesses and about half a million deaths a year. 

Plasmodium falciparum causes malaria in humans by destroying human haemoglobin through falcipain-2 (FP2). 

"The control of malaria has been hindered by increasing resistance of malaria parasites to available drugs. New anti-malarial drugs, ideally directed against new targets, are urgently needed," said the researchers. 

To counter this challenge, the team from Insilico Taiwan extensively studied the mechanisms by which the protease inhibitor E64 approaches, interacts with, and inhibits FP2. 

The results showed that the binding of E64 and FP2 are facilitated by the "amino acids of FP2 located within and nearby the previously identified binding pocket of FP2". 

This suggests that the anti-malarial drug design should not only focus on finding drug candidates that will bind tightly to the residues of established binding pocket, but also consider the need for the drug candidate to be able to bind to the residues surrounding the established binding pocket subsites.

"Insilico Taiwan is happy to present the work on malaria which potentially can help save millions of lives", says Artur Kadurin, CEO, Insilico Medicine Taiwan.

"It is a fascinating experience for me working with our team on solving the malaria which remains one of the deadliest diseases killing about half a million people annually", added Dr Emmanuel Salawu who holds a PhD in Bioinformatics.
 



Read more news:



Top 3 Ways to Make a Website Design More Accessible and Successful



India witnessing heavy cyber attacks from Russia, US, China


Source: IANS
SPOTLIGHT
Technology
Facebook-owned messaging app WhatsApp is still developing its previously announced "Vacatio..
Enterprise IT
Taking on streaming giants like Netflix and Hulu, Walt Disney Co. has announced it will laun..
Business
The Pentagon has selected Microsoft and Amazon Web Services (AWS, the cloud computing arm ..
Career
Wiley, a global leader in research and education has announced a series of blended learning progr..
Gadgets
Google Pixel and OnePlus smartphones are catching up and giving stiff competition to Samsu..
US Indian
Facebook-owned photo messaging app Instagram has launched the beta version of its in-app sh..
Finance
The Reserve Bank of India injected a total liquidity of Rs 2.98 lakh crore in the market in 20..
Entertainment
"Game of Thrones" author George R.R. Martin doesn't want season eight to be the final chapter of "..
Startup City
Youth are leading India's start-up ecosystem where the median age of founder-entrepreneurs..