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IIT Delhi's New Brain Cancer Treatment Shows Promise in Pre-Clinical Trials
Researchers at the Indian Institute of Technology (IIT) Delhi have reported promising results in pre-clinical trials for a novel nanoformulation aimed at treating deadly brain tumors. Glioblastoma, the most prevalent and aggressive type of cancerous brain tumor in adults, presents considerable treatment challenges despite existing options such as surgery, radiation, and chemotherapy. Patients diagnosed with glioblastoma typically face a life expectancy of only 12-18 months following diagnosis.
The research team created a new nanoformulation called Immunosomes, which merges a CD40 agonist antibody with the small molecule inhibitor RRX-001. Their innovative approach, detailed in the journal Biomaterials, seeks to improve the effectiveness of brain tumor treatments, providing a promising avenue for enhancing outcomes in glioblastoma patients.
During this study, mice with glioblastoma who received Immunosomes demonstrated complete elimination of tumors and remained free of tumors for at least three months. Moreover, the treatment induced a robust immune response in the host to combat brain cancer. After three months, researchers re-introduced glioblastoma cells to the mice that had survived long-term.
Interestingly, mice that received pre-treatment with Immunosomes exhibited minimal tumor growth, suggesting that Immunosomes might establish enduring immune memory capable of preventing future tumor recurrence without additional therapy. Furthermore, in addition to providing sustained protection against glioblastoma, Immunosomes treatment has the potential to mitigate the toxicity associated with CD40 agonist antibody, a challenge faced by clinicians worldwide.
"We are highly motivated by these results, and are excited to translate these findings to human clinical trials with a wider range of glioblastoma patients", said Dr Jayanta Bhattacharyya, Associate Professor, Centre for Biomedical Engineering, IIT Delhi.
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