NOVEMBER 20258iTOP 10 STARTUPS BREWING THE NEXT BIG WAVE IN PERSONALIZED GUT HEALTHBy M R Yuvatha, Senior Correspondent, Startupcity Columnn a world where gut feeling takes on literal meaning, the human microbiome trillions of bacteria, fungi, and other microbes in our digestive tract holds the key to everything from digestion and immunity to mood and metabolism. As of October 2025, the global probiotics market is surging toward $100 billion, fueled by post-pandemic awareness of preventive health.But generic pills?So last decade. Enters personalized nutrition brewer-ies, startups harnessing microbiome mapping and in-novative fermentation to craft custom probiotic drinks that target individual gut profiles. These ventures blend biotech with beverage artistry, fermenting tailored elix-irs from kombucha bases to probiotic sodas, promising a revolution in functional foods.The Science of Personalized Gut HealthAt the core of this movement lies microbiome mapping, a process where startups analyze stool samples via DNA or RNA sequencing to profile a user's unique bacterial composition. This reveals deficiencies, such as low levels of beneficial strains like Akkermansia for glucose
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