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India-Born Scientist's Team Uses DNA Rings For Cancer Detection
WASHINGTON: U.S. researchers led by India-born physician-scientist Sanjiv Sam Gambhir have developed a futuristic method of using tiny customised DNA rings for early detection of cancer.
The DNA rings, carrying instructions for making a blood-detectable biomarker, can enter both healthy cells and cancer cells. But only cancer cells follow the recipe to make the biomarker.
Stanford University School of Medicine investigators inserted tiny DNA minicircles into the genes of mice, which caused cancer cells to emit a substance that could be detected from a blood sample.
The scientists then showed that mice with tumours produced a substance that tumour-free mice did not make. The substance was easily detected 48 hours later by a simple blood test.
"We want to translate this strategy into humans, so we've set it up in a way that's most likely to be effective, safe and convenient," said Gambhir, who is also the Virginia and D.K. Ludwig Professor for Clinical Investigation in Cancer Research.
Ambala-born Gambhir, 53, moved to the US with his parents and sister in 1969. He was raised in Phoenix, Arizona. He is married to Aruna Bodapati Gambhir, has one son and lives in the Bay Area.
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Source: IANS
